SIMPLER NUCLEOTIDES FROM YEAST NUCLEIC ACID

The Structure of Yeast Nucleic Acid

The tetranucleotide theory of the structure of yeast nucleic acid was first enunciated by the writer1 and was subsequently conclusively demonstrated by the experimental evidence furnished by Levene and Jacobs,2 ‘and by Levene and La Forge.3 The facts on which the theory was based were: first, the isolation of four nucleosides; second, the isolation of simple pyrimidine nucleotides. These were o...

The Structure of Yeast Nucleic Acid

Levene and Jacobs have formulated the structure of yeast nucleic acid as a tetranucleotide. The facts that led up to their formulation were: 1. The formation of four nucleosides on neutral or ammonia hydrolysis. 2. The formation of simpler nucleotides on hydrolysis with dilute mineral acids. 3. The presence of a phosphorus to nitrogen ratio which agreed quite well for t.he tetranucleotide theor...

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides

Thermodynamics provides insights into the influence of modified nucleotide residues on stability of nucleic acids and is crucial for designing duplexes with given properties. In this article, we introduce detailed thermodynamic analysis of RNA duplexes modified with unlocked nucleic acid (UNA) nucleotide residues. We investigate UNA single substitutions as well as model mismatch and dangling en...

Nucleosides, Nucleotides and Nucleic Acids

To cite this article: Krzysztof Komodziński, Zofia Gdaniec & Bohdan Skalski (2015) Photochemical Behavior of 2-Azidopurine Tri-O-Acetylribonucleoside in Aqueous Solution: Unprecedented Transformation into 1-(5′-O-Acetyl-β-D-Ribofuranosyl)-5-[(2-Oxo-1,3,5Oxadiazocan-4-Ylidene)Amino]-1H-Imidazole-4-Carbaldehyde, Nucleosides, Nucleotides and Nucleic Acids, 34:4, 235-245, DOI: 10.1080/15257770.2014...

Nucleosides, Nucleotides and Nucleic Acids